2025, Volume 71(75), Issue 4 (December), pp. 105 - 116

Optimization of the Preparation Parameters of PCL Particles Obtained by an Emulsification/Evaporation Method

OANA CUCOVEICA, “Gheorghe Asachi” Technical University of Iași, “Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection, Iași, Romania; Faculty of Medicine, Apollonia University of Iași, Iași, Romania, oanacucoveica@yahoo.com
LEONARD IONUȚ ATANASE, “Gheorghe Asachi” Technical University of Iași, “Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection, Iași, Romania; Faculty of Medicine, Apollonia University of Iași, Iași, Romania; Academy of Romanian Scientists, Bucharest, Romania

pages 105 - 116   Download
DOI: 10.5281/zenodo.19660537

Abstract
Nanotechnology represents a sector with high potential for the treatment of human diseases. Among different types of drug delivery systems, polymer nanoparticles (NPs) are of main importance in the biomedical field. They are mainly used as vehicles for the delivery of active compounds, thus protecting the drug against enzymatic and chemical degradation and directing it to the various target tissues and cells. Many factors can influence the size of NPs such as stirring speed, polymer concentration, organic phase addition speed or surfactant concentration. The aim of this study was to find the optimum conditions for the preparation of nanoparticles using an emulsification/evaporation method. Using dynamic light scattering technique, it was possible to assess the optimal conditions for the preparation of NPs with size less than 200 nm, such as: 1 wt. % concentration in CHCl₃, 1 wt. % concentration of PVA in the aqueous phase and 5 min homogenization. These optimized parameters ensure a stable and monodisperse colloidal suspension suitable for future parenteral administration.
Keywords: poly(ε-caprolactone), drug delivery systems, optimization parameters, dynamic light scattering, colloidal stability.